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O027-05 Comparitive Study of Patients with Residual Organic Mental Disorders of Traumatic and Non-Traumatic Origin Andrey Khachaturyan, National Institute of Health, Psychoth. and Med. Psychology, 47, Nalbandyan str. apt. 3, 375025 Yerevan, Armenia, Email: andrei freenet.am Objective: In reports that argue that `Postconcussional disorders' must be recognized in nosology' the main accent is shifted towards the problem of organic psychogenic origine of pathology. On the assumption that postconcussional syndrome is a variety of residual organic mental disorders the question arises if there are any differences between contingents of patients with traumatic brain injury and with other types of residual organic pathology. Method: Catamnestic data of 395 outpatients of Yerevan Psychoneurologic Dispensary with the sequelae of brain trauma n 217 ; and other types of brain injuries n 178 ; were evaluated according to unifide program. Results: Substantial disproportion in men women ratio, predominance of patients first admited to psychiatric department at the age of 40-45 years and prevalence of mental disorders of neurotic and depressive spectrum in after-traumatic group was revealed. Conclusion: Obtained data lead to suggestion that mental disorders after craniocerebral trauma in a greater degree interfere with occupational problems. References: Belov VP, Khachaturyan 1997 ; : Dinamic featutures of social and occupational adjustment levels of patients in the late period of traumatic head injury, Socialnaja i klinicheskaia psikhiatria. 7 3 38-45 Belov VP, Khachaturyan 1999 ; : Personality disorders after a head injury, Zhurnal nevrologii i psikhiatrii imeni S.S.Korsakova. 99 10 14-20.

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This drug is either given by mouth or placed within the vagina birth canal and erythromycin. Lignant syndrome: case report and literature review. Drug Intelligence and Clinical Pharmacy 22: 475480, 1988 Susman VL, Addonizio G: Recurrence of neuroleptic malignant syndrome. Journal of Nervous and Mental Disease 176: 234241, 1988 Rosebush PI, Stewart TD, Gelenberg AJ: Twenty neuroleptic rechallenges after neuroleptic malignant syndrome in 15 patients. Journal of Clinical Psychiatry 50: 295298, 1989 Levenson JL, Fisher JG: Long-term outcome after neuroleptic malignant syndrome. Journal of Clinical Psychiatry 49: 154156, 1988 Pope HG, Aizley HG, Keck PE, et al: Neuroleptic malignant syndrome: long-term follow-up of 20 cases. Journal of Clinical Psychiatry 52: 208212, 1991 Gelenberg AJ, Bellinghausen B, Wojcik JD, et al: Patients with neuroleptic malignant syndrome histories: what happens when they are rehospitalized? Journal of Clinical Psychiatry 50: 178180, 1989 Fernando MLD, Manchanda R, Kirk C: Neuroleptic malignant syndrome: a preventative program. Journal of Psychiatry and Neuroscience 17: 3133, 1992 Creese I, Hamblin MW, Leff SE, et al: CNS dopamine receptors, in Handbook of Psychopharmacology, Vol 17. Edited by Iversen LL, Iversen SD, Snyder SH. New York, Plenum, 1983 63. Velamoor VR, Norman RM, Caroff SN, et al: Progression of symptoms in neuroleptic malignant syndrome. Journal of Nervous and Mental Disease 182: 168173, 1994 Caroff S, Rosenberg H, Gerber JC: Neuroleptic malignant syndrome and malignant hyperthermia ltr ; . Lancet 1: 244, 1983 Downey GP, Caroff S, Beck S, et al: Neuroleptic malignant syndrome patient with unique ethical and physiologic features. American Journal of Medicine 77: 338340, 1984 Tollefson G: A case of neuroleptic malignant syndrome: in vitro muscle comparison with malignant hyperthermia. Journal of Clinical Psychopharmacology 2: 266270, 1982 Scarlett JD, Zimmerman R, Berkovic SF: Neuroleptic malignant syndrome. Australian and New Zealand Journal of Medicine 13: 7073, 1983 Bond WS: Detection and management of the neuroleptic malignant syndrome. Clinical Pharmacology 3: 302307, 1984 Blair DT, Dauner A: Neuroleptic malignant syndrome: liability in nursing practice. Journal of Psychosocial Nursing and Mental Health Services 31: 512, 1993 Lannas PA, Packar JV: A fatal case of neuroleptic malignant syndrome. Medicine, Science, and the Law 33: 8688, 1993 Lazarus A: Should neuroleptic malignant syndrome be treated in a private psychiatric hospital or a general hospital? General Hospital Psychiatry 12: 245247, 1990.
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An 800 number to call for further information that could be mailed, faxed, or read to the consumer; 2 ; a reference to a contemporaneous print advertisement that contained the brief summary of risk information; 3 ; a website address where there would be more information about the drug, including the package insert; or 4 ; a reference that more information could be obtained from a physician, pharmacist, or other health professional. FDA said that it wanted the industry to conduct studies to measure the public health impact of its advertising. The draft notice said FDA would evaluate the policy in two years.45 The "draft guidance" lead to more television advertising. Drug companies, on issuance of the draft guidance, immediately redirected some of their advertising spending from print to television. In subsequent budget cycles, they directed most of the increased spending to television. DTC advertising on television grew to $579, 000, 000 in 1998.46 The new policy was implemented with its share of problems. In the first year after its issuance, virtually all of the DTC commercials that appeared on television and that had not been reviewed in advance by DDMAC -- about half of all the television advertisements that appeared -- were the subject of FDA enforcement actions.47 FDA took the public view that this was the cost of adopting a new policy. In the second year after the issuance of the "draft guidance, " the number of enforcement actions declined substantially.48 In August 1999, FDA issued a final guidance on DTC television advertising.49 The guidance "represents the Agency's current thinking on procedures to fulfill the requirements for disclosure of product information in connection with consumer-directed broadcast advertisements for prescription human and animal drugs, and human biological products."50 It applied to television, radio, and telephone communications systems. The final guidance represented no significant changes in FDA policy on DTC advertisements on television. It said that the "adequate provision" requirement could be met by: 1 ; a toll-free number for consumers to call to receive the approved package labeling via mail or via being read to them on the phone; 2 ; reference to a print advertisement that should have a toll-free number or having a sufficient number of brochures available in publicly-accessible locations; 3 ; reference to an Internet site that provides access to the package insert; and 4 ; disclosure that health care professionals may provide additional product information.51 One significant addition to the guidance was the statement that print advertisements associated with broadly-disseminated broadcast commercials should be "comparably broadly disseminated in terms of the targeted audiences."52 This statement was intended to deal with the practice of television commercials for prescription drugs pointing to print advertisements in obscure or lightly-circulated magazines. The guidance also addressed telephone advertisements that made a product claim. It said that such advertisements differed from television and radio advertisements because the consumer, by participating in the phone conversation, already indicated a willingness to discuss the topic or receive more information. Thus, FDA said "adequate provision" can be met with fewer requirements compared to radio and televiId. MED. ADVERTISING NEWS, supra note 29, at 19. 47 Author's conversation with John Kamp, Senior Vice President, Amer. Ass'n of Advertising Agencies, supra note 28. 48 Nancy Ostrove, FDA Division of Drug Marketing, Advertising and Communications, Remarks at the Drug Information Association Annual Meeting June 29, 1999 ; . 49 FDA, Guidance for Industry: Consumer-Directed Broadcast Advertisement, Aug. 1999, available at fda.gov cder guidance index . 50 Id. 51 Id. 52 Id and floxin.
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One common treatment with antiinflammatory treatment with some tablets, are immediaterelease, whereas volatren is extendedrelease. Author : S. Sayuthi, J. Abdullah, J. Tharakan, J. George, A. Prasad, A. R. Arif, NA. Wahab, A. Rahman, S. Awang, Z. Idris Institution : Neuroscience Unit, School of Medical Science, USM1; Department of Pathology, School of Medical Science, USM2; Department of Radiology USM3 Introduction : There are scanty reports of elderly patients presenting with Caroticocavernous Fistula CCF ; and having two unruptured arteriovenous malformations AVM ; Objective : A case report involving a female patient with CCF and dual AVM is presented Methodology : 76year old diabetic malay lady presented with two months history of progressive deterioration of vision with blurring looking at distance until vision only at two feet and conjunctiva redness without history of trauma. Examination reveal conjested retina, no exopthalmos and restricted eye movement almost to all direction except left lateral gaze. There were no orbital pulsatile bruit on auscultation. Her CT brain scan shown bilateral dilated superior orbital veins, and her cerebral angiogram show Carotico-cavernous Fistula from branches of right ECA type D ; . There are also two AVM situated in the orbit and territory of middle meningeal artery. Type D CCF, usually have a spontaneous onset and are low velocity fistulas. Dural CCF is usually found in elderly women, many of which are congenital arteriovenous malformations that develop spontaneously. The symptoms and signs produced are influenced by the size of the fistula, location within the cavernous sinus, rate of flow and drainage vessels. Anteriorly draining dural fistulas show signs of orbital congestion similar to that in direct CCF but are much more subtle while posteriorly draining fistulas are usually asymptomatic or in some cases may manifest as isolated cranial nerve palsy. As this condition presents with subtle features of orbital congestion or as cranial nerve palsy, it is commonly misdiagnosed clinically as conjunctivitis, glaucoma, retinal vascular disorder, isolated cranial nerve palsy, and thyroid ophthalmopathy. So far, there are no reported cases of spontaneous CCF associated with AVM in the English literature Conclusion : The incidence of spontaneous Caroticocavernous Fistula CCF ; associated with Arterio-venous malformation AVM ; is rare, and can be successfully treated by transarterial embolisation.