In the following theoretical example, replacement of a cytidine c ; with a guanine g ; in the gene results in formation of an amino acid with completely different properties: instead of the large, basic amino acid glutamine gln ; , the small, neutral amino acid glycine gly ; is formed.
JPET #97030 Kourie JI 1998 ; Interaction of reactive oxygen species with ion transport mechanisms. Am. J. Physiol. 275 Cell Physiol. 44 ; : C1-C24. Lee C and Okabe E 1995 ; Hydroxyl radical-mediated reduction in Ca2 + -ATPase activity of masseter muscle sarcoplasmic reticulum. Jpn. J. Pharmacol. 67: 729-734. Lindstrom EG and Andersson RG 1997 ; Neurokinin A-LI release after antigen challenge in guinea-pig bronchial tubes: influence of histamine and bradykinin. Br J Pharmacol 122: 417-422. Liu L, Shang F, Markus I and Burcher E 2002 ; Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease. J Pharmacol Exp Ther 302: 627-635. Lu G, Qian X, Berezin I, Telford GL, Huizinga JD and Sarna SK 1997 ; Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal. J Physiol 273: G1233-1245, for example, patient information.
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210208 SPECIALIZAN ODBORN ST NOV TRENDY LABORATORN DIAGNOSTIKY V IMUNOLOGII Ureno pro vysokokolky nelkae pracujc v oboru nebo zaazen do speciln prpravy z vyetovacch metod v klinick imunologii Program: kolitel: Msto konn: Datum: Teoretick i praktick poznatky o prtokov cytometrii, imunogenetickch vyetovacch metodch a transplantologii prof. MUDr. Ivo Hna, CSc.; RNDr. Vlastimil Krl, CSc. IKEM, Praha 4, KHS, st nad Labem 1.-5. 9. 2003.
This is a good medicine and my son has not developed any side effects so far, for instance, zocor.
Statins are generally very well tolerated with few adverse effects. The main contraindications of statins relate to their potential adverse effects on the liver and skeletal muscle that may be increased by other concomitant medications such as fibrates. Other contraindications include women of child-bearing potential, pregnancy, breast feeding and porphyria. Statin therapy can lead to elevations in liver enzymes, particularly transaminases. Patients with active liver disease should, therefore, not receive statin therapy. Transient rises in the transaminases are common early after initiation of statin therapy but rarely 1% ; rise above three times the upper limit of normal. It is recommended that liver function tests are documented before initiating treatment and monitored for at least the first few months of therapy.
The dichlorodifluoromethane shall conform to the requirements of type 12 of BB-F-1421 when tested as specified therein 3.1.4 page 5 ; . Determine the percent by weight of dichlorodifluoromethane insolubles in the allethrin 4.2.4.1 page 10 ; . CFC 12 BB-F-1421 ODS CHEM 2: Comments: BB-F-1421 has been proposed for Cancellation by Proposed Notice 1, dated 31 March 1995, and is superseded by ARI Standard 700 and ARI Appendix 93. NAVSEA 03V24 and 03V23 have replied to Air Force SAALC SFSP that ARI 700 adequately covers refrigerants but does not adequately cover packaging for delivery. Navy recommends a CID or some other document be developed to be used in conjunction with ARI STD 700 to cover the acceptable packaging options that can be specified by the procuring activity these were covered in BBF-1421 and microzide.
Children: there is no experience with the use of emeset tablets or solution in the prevention of radiation-induced nausea and vomiting in pediatric patients.
0.1 gm. substance gave 0.0412 gm. Mg, P&. P 11.5 per cent theoretical 11.7 per cent and eulexin!
PIO treatment proved to be non-inferior to INS treatment regarding the following objectives: Mean total treatment costs were 1, 207 C PIO ; and 1, 510 C INS ; Fig.1 ; Reduction in HbA1C per 1, 000 C Fig. 3 ; Cost per 0.5 %points reduction in HbA1C Fig. 3 ; Costs are predominantly associated with macrovascular diabetes complications Fig. 4a 4b ; . Patients treated with INS and those treated with PIO differed with regard to the frequency of macrovascular complications 17.4% vs. 8.0%, respectively ; . When focusing on those patients without macrovascular complications, no differences in terms of cost proportion compared to the total study population were revealed. Self monitoring of blood glucose PIO: 89 C , INS: 326 C ; as well as total treatment cost antidiabetic medication + glucose self-monitoring ; for diabetes INS: 774 C, PIO 646 C ; differed between both treatment arms Fig. 2 ; . Patient Profile: PIO dominated the INS alternative especially in insulin resistant, obese patients BMI 26 kg m2 ; diabetes duration 5 years Fig. 5-8.
Otulinum toxin A may be an effective method of treating lumbar-sacral paravertebral and trapezius muscle pain secondary to spasm, according to data from a single-center, retrospective chart review. The chart review included 19 patients treated with Botulinum toxin type A for isolated lumbar-sacral 14 out of 19 patients ; and or trapezius 6 out of 19 patients ; pain secondary to severe muscle spasms--one patient was injected in both areas. Pain duration in the 20 muscle sites was 3 months or more, with all patients unresponsive to nonsteroidal antiinflammatory drugs or physical therapy. Improvement following 0.25% bupivacaine injected to the active motor nerve endplate within the affected muscle was a screening requirement. Botulinum toxin type A 75-200 U ; was injected to the active motor endplate, identified by using a transcutaneous nerve stimulator followed by transdermal needle electrode or by EMG guidance. Patients were followed for up to 3 months postinjection. Pain was quantified using a numeric rating scale NRS ; of 0 to 10, with 10 indicating the worst pain. It appeared there was an 89% improvement in the mean 0-10 NRS score by week 2, and that complete pain relief was achieved for 63% of and flutamide.
Benzyloxyresorufin matches the hydrogen bond acceptor HBA1 Fig. 3A ; . This oxygen atom may accept a hydrogen atom and form a hydrogen bond with the enzyme or a water molecule in the active site. All functions in the pharmacophore B were fit by 7-EFC Fig. 3B ; . One of the rings fits the hydrophobic function H3, and the trifluoromethyl group fits another hydrophobic function H4. Both of them may also form hydrophobic interactions with the enzyme. The oxygen atom on the ring fits the hydrogen bond acceptor HBA2 and may form a hydrogen bond with CYP2B6 or a water molecule in the active site.
Caregiver Self-Efficacy and Childhood Unintentional Injury: Injury Prevention Behavior as a Mediator Shanna M. Guilfoyle, Bryan T. Karazsia, Beth G. Wildman, Psychology, Kent State University, Kent, OH Purpose: Childhood unintentional injury CUI ; is the leading cause of death to children. Recent works have highlighted the need for greater application of behavioral-change theories to CUI prevention e.g., DiGuiseppi & Roberts, 2000; Gielen & Sleet, 2003 ; . Although the Health Belief Model Becker, 1974 ; provides a framework to enhance child safety, we propose the application of Protection Motivation Theory PMT; Prentice-Dunn & Rogers, 1986 ; to CUI prevention. PMT may provide unique theoretical contributions that assist to identify underlying caregiver traits that influence CUI Morrongiello, 2005 ; . The current objective was to evaluate caregiver sense of parenting efficacy and how much caregivers engaged in injury prevention behavior. Using PMT to guide choice of variables and raloxifene.
This dissertation takes fashion seriously, since it has been hypothesized that fashion is a genuine social mechanism with broad explanatory potential in organizational analysis. One can not deny the importance, in both magnitude and intensity of the management fashion phenomenon. Managers are confronted daily with new popular management concepts, which are often considered a transitory facade, showing high rates of failure when implementing. On the other hand, it can be argued that management fashions offer potential benefits, since managers purchase what they should know as transitory prefabricated concepts. In addition, classic management concepts, which can be theorized to be different from their fashionable counterparts are available and are wide spread. Classic management concepts are continuously communicated and bear the same labels over time. On the other hand, fashionable concepts possess by definition a transient character and have trendy names. Since the neo-institutional fashion theory is deficient in the viewpoint to the apparatus behind interpretation and shaping of fashions, the main research question addressed in this work is "How do managers consume i.e., interpret and shape ; both new popular and classic management concepts?" This research question build on following factors: the view that most research in business strategy and organization since the 1990s has pointed to external factors that gave rise to new organizational forms and routines NOFaR the fact that communication regarding these NOFaR has been summarized by various new popular management concepts and has been set out by a variety of transmission agents; and doubts as to whether NOFaR accurately captures the nature of contemporary organizational change. In order to provide an answer on the research question and to which factors influence consumption of management concepts, we used a cognitive approach permitting a multi-level comparison of actors' mental models about management concepts. The methodology employed for elicitation of mental models was the Repertory Grid Technique RGT ; . Two studies were designed. The first study focused on analyzing how top-level decision makers consume new popular and classic concepts. The second study consisted of an Internet self-administered questionnaire administered in the form of a repertory grid matrix, aiming at a broader sample possessing different managerial levels and individual backgrounds. In both studies, WMDS was employed. Both studies revealed that the aggregate mental models about management concepts are complex and that managers explicitly possess mental models about both new popular and classic management concepts. Although theoretical differences between new popular and classic management concepts exist and the fact that both types of concepts are recognized as such, it may be concluded that new popular management concepts and classic concepts are not so different anyway, at.
This case-control study was conducted at National Institute of Mental Health and Neurosciences NIMHANS ; , a tertiary referral center in Bangalore, South India. Thirty-five consecutive adult patients clinically diagnosed as PD cases were recruited from the Neurology Out-patient Clinic, for this study. Patients were and efavirenz.
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Synopsis According to a systematic review published in the Bulletin of the World Health Organisation, fixed-dose combination pills and unit of use packaging are likely to improve adherence in a range of settings, but the limitations of the available evidence means that uncertainty remains about the size of these benefits. The systematic review included 15 randomised trials, to quantify the effects of fixed-dose combination pills and unit-of-use packaging, compared with medications as usually presented, in terms of adherence to treatment and improved outcomes. The trials involved treatments for communicable diseases n 5 ; , blood pressure lowering medications n 3 ; , diabetic patients n 1 ; , vitamin supplementation n 1 ; and management of multiple medications by the elderly n 5 ; . According to the authors, the results of the trials suggest that there were trends towards improved adherence and or clinical outcomes in all but three of the trials; this reached statistical significance in four out of seven trials reporting a clinically relevant or intermediate end-point, and in seven out of thirteen trials reporting medication adherence. Measures of outcome were, however, heterogeneous, and interpretation was further limited by methodological issues, particularly small sample size, short duration and loss to follow-up. Title Hospitalisation and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents Arch Intern Med 2005; 165: 68-74 Abstract and sustiva.
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Crosomes, and 3-hydroxyquinine is the main metabolite of quinine in these animal livers Zhao and Ishizaki, in press ; . On the other hand, etoposide, a commonly used anticancer agent with a broad range of antitumor activity, is claimed to be metabolized largely via CYP3A4 by 3 -demethylation in human liver microsomes and its metabolite has some antitumor activity Relling et al., 1992 ; . Like quinine, etoposide also possesses a relatively low therapeutic index with some adverse reactions in cancer patients e.g. leukopenia ; Kobayashi and Ratain, 1994 ; . Therefore, from a theoretical point of view, a drug-drug interaction might occur when quinine and etoposide are co-administered in patients with cancer who are living in malaria endemic areas such as Southeast Asia, South America, and East Africa i.e. 300 to 500 million new cases of malaria every year ; . More importantly, if a mutual inhibition between quinine and etoposide in human liver microsomes would occur, it should provide further evidence for the role of CYP3A4 involvement in the metabolism of both quinine and etoposide. Based on the background as discussed above, we conducted this study to assess the mutual interaction potential of quinine and etoposide in vitro, as well as to confirm further that etoposide and quinine are metabolized mainly via CYP3A in human liver microsomes and ethambutol.
Three new members of staff took up duty: Dr. Tracy Keane and Dr. Patrick Costello as additional Immunological Assessors in the Veterinary area, Dr. Lorraine Nolan as Project Manager Controlled Drugs to oversee the transfer of that function from the Department of Health and Children to the IMB over the next twelve months, Ms Trina O'Neill as Assistant Accountant, Ms Kathleen O'Neill, Senior Pharmaceutical Assessor has rejoined the staff following a career break.
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Alteration of medical records includes using whiteout, highlighting, and changing words. Any corrections needed on a medical record should be crossed out with a single line, dated and initialed by the person making the correction. An addressograph should be stamped on every page of the medical record, or the patient's name can be hand written. The patient's name cannot be written on photocopies of medical documentation; this is not acceptable and considered alteration of medical records and cause for claim denial. The intentional fabrication or alteration of medical records in order to improve a facility's billing position with Medicare constitutes falsifying business records in the first degree. Refer to Medicare News Update Special Edition #2 dated March 1996, Special Edition #9 dated December 1997, and Medicare News Update 2002-2 and myambutol and oretic, for example, medicines.
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Commonly in pathological conditions associated with arterial disease or where there is stasis. The formation of a thrombus is in vivo unlike blood clots which can form in vitro ; . Pieces of the thrombus may break off and form an embolism, which may lodge in vessels in the lungs or brain causing damage to the tissues supplied. Thrombolytic drugs are able actually to dissolve thrombi. In contrast, neither antiplatelet drugs nor anticoagulants are thrombolytic. However, antiplatelet drugs normally given prophylactically diminish the adhesion of platelets, and thus reduces their potential contribution to thrombus formation see PLATELET ADHESION INHIBITORS ; . Similarly, anticoagulants particularly when used prophylactically can protect individuals at risk of thrombus formation. It is often beneficial to give agents from two or three of these classes in concert vide infra ; . Regarding intrinsic fibrinolytic factors in the body, when the `intrinsic' coagulation system is activated, the fibrinolytic system is also set in motion, and the latter involves endogenous plasminogen activators. The endogenous activators are of two types tissue-type plasminogen activators t-PA ; and urokinase-type plasminogen activators u-PA ; . The main role of the t-PA is fibrinolysis, and that of u-PA is mainly in cell migration and tissue remodelling processes. In the blood, some plasminogen activator derives from the vascular endothelium and from phagocytic cells, or by the action of factor XII on pro-activators in plasma and or tissues. Plasminogen is a serum -globulin MW 143000 ; that is deposited on fibrin strands within the thrombus. The plasmogen activators, which have a short half-life in the bloodstream, are serine protease enzymes that split a Arg-Val bind in plasmogen, to release the enzyme plasmin also known as fibrinolysin ; . Plasmin is a trypsin-like serine protease that acts on Arg-Lys bonds to digest many blood components, including fibrin, fibrinogen and factors II, V, VIII and a number of other proteins. Plasmin is normally formed only locally within the clot since plasminogen is adsorbed onto fibrin, and is rapidly broken down in the bloodstream. There is a second mechanism for stimulating fibrinolysis involves activation of protein C, a coagulation inhibitor. Turning to fibrinolytic agents used medically to enhance or mimic the normal fibrinolytic processes, and dissolve thrombi, there are only a few agents available. The most commonly used is streptokinase, a non-enzymic protein obtained from cultures of Streptococcus haemolyticus, which acts indirectly by forming a stable complex with plasminogen, and imparts greater activity to that enzyme through the conformational change. Though effective, there may be a dangerous sensitivity reaction to this foreign protein. Anistreplase APSAC ; is a complex of human Lys-plasminogen and streptokinase, and is used in acute myocardial infarction. Of plasminogen activators similar to those found normally in vivo, alteplase is a single chain recombinant tissue-type plasmin activator, whereas duteplase is a double chain recombinant tissue-type plasmin activator. Urokinase tca-PA or r-scu-PA ; is an endogenous serine protease with many actions, that binds to a urokinase receptor found on the membrane of monocytes and other cells. It is normally secreted from cells as a single-chain proenzyme scu-PA ; from which the double-chain active form tcu-PA ; is derived by proteolysis. Clinically, tcu-PA urokinase is the form used which is derived from human embryonic kidney cells ; , and acts directly as a plasminogen activator. Also under development is saruplase recombinant human single-chain urokinase-type plasminogen activator, r-scuPa urokinase ; , which is converted to urokinase on binding to fibrin.
Ritonavir-boosted Protease Inhibitors PI rtv ; are exclusively recommended over non-boosted PIs ; because they have been shown to have greater and more consistent benefit in clinical trials and in cohort studies. This is due to the ability of low dose ritonavir to inhibit cytochrome P450 resulting in enhanced bioavailability of several protease inhibitors. Lopinavir rtv LPV co-formulated as LPV rtv, also known as Kaletra ; , atazanavir rtv TAZ rtv, ATZ rtv, or Reyataz ; , fos-amprenavir rtv fos-amp rtv, Telzir ; or saquinavir rtv Invirase ; are the generally preferred PI-based choices for initial therapy. Until recently, most of the data currently available in support of PI rtv use was based on clinical trials and cohort studies involving lopinavir rtv. However, recent data suggests that atazanavir rtv and fos-amprenavir rtv are comparable to lopinavir rtv, in terms of overall antiviral efficacy, with some differential tolerability and safety features. Saquinavir rtv is also an acceptable PI rtv option, particularly since the new formulation of saquinavir Invirase 500 mg tablets ; is associated with a lesser pill burden and less GI side effects. Ritonavir as a single PI, nelfinavir, non-boosted amprenavir and indinavir are not currently recommended. Similarly, non-boosted atazanavir, saquinavir and fos-amprenavir are not recommended. Of note, the currently available capsule formulation of ritonavir requires refrigeration for long-term storage. LPV r has been co-formulated as Kaletra, which contains 133.3 mg lopinavir + 33.3 mg ritonavir, and is prescribed at a dose of 3 capsules 400 mg lopinavir 100 mg ritonavir ; twice daily after a meal for initial therapy. More recently a new heat stable tablet formulation of LPV rtv has become available. The new LPV rtv tablet does not require refrigeration, produces less GI side effects including less diarrhea ; and has increased bioavailability, which in turn is associated with a lesser pill burden. The current recommended dose of LPV rtv tablet is two tablets twice a day or four tablets once a day, for initial therapy. Lipid abnormalities may occur in patients receiving LPV rtv. Of note, the BC-Centre pharmacy will be offering an automatic switch to LPV rtv tablets at the equivalent dose to stable patients on soft gel LPV rtv, starting in the fall of 2006. Atazanavir TAZ ; 300 mg with 100 mg ritonavir RTV or Norvir ; , once daily after a meal is also recommended as initial therapy. TAZ rtv should not be co-administered with acid-lowering medications proton-pump inhibitors or H2 receptor antagonists ; because these agents can up to 50% ; reduce the bioavailability of TAZ. Benign hyperbilirubinemia is commonly seen in patients prescribed TAZ. Mild lipid abnormalities can be seen with TAZ rtv. Skin rashes can occur with TAZ. Fos-amprenavir fosAPV, FPV or Telzir ; 700 mg and ritonavir 100 mg twice daily is recommended for initial therapy. Fosamprenavir 1400 mg and ritonavir 200 mg once daily can also be used as initial therapy. The main side effect associated with fosamprenavir is skin rash in about one fifth of patients. Mild lipid abnormalities can be seen with ritonavir-boosted fosamprenavir. INV500 is the new formulation of saquinavir, which contains 500 mg of SQV in each tablet. The recommended dose is SQV1000 mg with 100 mg ritonavir twice daily or SQV rtv 2000 100 mg, respectively once daily for initial therapy. Mild lipid abnormalities can be seen with ritonavir-boosted saquinavir. Gastrointestinal intolerance was relatively common with the soft-gel formulation of saquinavir Fortovase ; , which is no longer in use and etoposide.
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Shown in Fig. 2 is a stability region where B 20[packets ms], ~ l[ms], and -y 3. Note that B 20 corresponds to 163.8 [Mbit s] if the packet length is equal to 1 [Kbyte]. In this figure, the dotted and solid lines correspond to Eqs. 11 ; and 12 ; , respectively. When the number N of connections are less than 20, J can be taken larger as N increases. But when it is greater than 20, J should be smaller as N increases. It is shown that the network is always st able for any N 0 if less than one. Moreover, since the dotted line converges to IS 2, for sufficiently large number of connections, we take J less than 2 for the network to be stable. Equation 5 ; is regarded as static feedback with feedback gain d from the control theoretical point of view. So, in general, if J is set to be larger, that is, we use high gain feedback, then transient behaviors of the network will be better while stability will be worse. Figure 2 shows such a tendency. Shown in Figs. 3 and 4 are behaviors of the window size and the queue length for N 10 when the network are stable and unstable, respectively. When the net work is stable, both the window size and the queue length converge to the fixed point given by Eq. 8 ; . However, when it is unstable, they oscillate with large amplitude, which implies that transmission delay of packets becomes very large. Moreover, the buffer becomes empty of the periodically, which implies that the throughput network degrades. Thus, it is concluded that 8 has to be selected such that the network is stable.
During the preparation of this work, some interesting questions arose for which time and space did not allow a further investigation. However, they might serve as a starting point for future research: We have shown forbidden submatrices to be a generalization of the Minimum Species Removal and Minimum Character Removal problem. Since any forbidden substructure problem on bipartite graphs can be stated as a forbidden submatrix problem on the respective graphs adjacency matrix: What other problems can be related to the removal of forbidden submatrices? Are there problems that can be related to the removal of -ary matrices? Can problems related to k-Perfect Phylogeny be connected to forbidden submatrix problems? Is Conjecture 4.19 true? What are examples for matrices for which we do not yet know whether this conjecture is true and how can they be characterized in general? Can the computational complexity of other submatrix-removal strategies such as the modification of individual entries or Row and Column Deletion ; be determined using the framework developed in this work? The problem of finding a minimum "feedback-vertex set" a set that contains at least one vertex from every cycle in the graph ; is known to be fixed-parameter tractable [DoFe99]--can it be connected to Graph Bipartization? Furthermore, we expect the Minimum Feedback Vertex Set problem to have a lot of biological problems closely related to it e.g., finding key reactions in metabolic networks ; --it therefore deserve some further research of its own. The developed reduction rules are only efficient for the presented problems relating to SNPs. The importance of Graph Bipartization in many areas of research as was mentioned in Chapter 6 ; could be a motivation to develop an efficient all-purpose software package to solve Graph Bipartization especially Vertex Bipartization ; problems. As we have seen, bringing together biology and theoretical ; computer science is a fruitful undertaking for both areas, with biological problems giving impulses for the systematic analysis of previously unstudied computational problems such as the Row Deletion problem in this work ; , and computer science providing tools and insights about chances and limits in various areas of biological research. This is the core idea behind the field of bioinformatics, from which we can hope to see more of this mutual nourishment in the near future as more and more people join in on connecting the life- and the computer sciences.
The term "anti-infective conversion" describes the practice of converting intravenous anti-infection therapy to an alternative oral formulation. This conversion from intravenous IV ; to oral PO ; therapy has been practiced in an uncontrolled fashion since the earliest years of the anti-infective era. As conversion therapy was based on empirical observations rather than on clinical studies or outcomes, there was concern that oral therapy was less effective. In addition, until recently, no clinical trials were available to support the conversion from the intravenous route to oral administration. Current forces that are accelerating the conversion from intravenous to oral therapy include rising health care costs, limited health care resources, efforts to shorten hospital stays, and demands by patients for cost-effective, safer, and more convenient treatments. This conversion has been referred to as "switch, " "sequential, " and "stepdown" therapy.1-3 For the purposes of this review, the concept is referred to as IV: PO conversion.
And resulted in a maintenance of lumbar BMD. However, both groups exhibited an unexpected and significant mean weight increase, and treatment effects were abolished after adjusting for weight gain. Both treatments resulted in significant decreases in bone resorption markers. Unlike HRT, DHEA exhibited anabolic properties, including enhanced levels of bone formation markers only in this treatment group and a positive correlation between increases in hip BMD and increases in IGF-I. Subjects receiving DHEA also exhibited favorable changes in specific psychological variables, as have been reported in studies of aging men and women who received DHEA treatment. In the current study we found that hip BMD, unadjusted for weight, increased, and spinal BMD was unchanged. Both groups exhibited significant weight gain, and the increase in BMD appeared to be attributable to both weight gain and corresponding IGF-I increases, the latter of which is a factor highly influenced by nutrition. Differentiating the effect of treatment on BMD from the effect of weight gain was difficult because of the surprising and striking weight gain exhibited in both groups. As DXA has difficulty in discriminating fat from bone 31 ; , we tested whether body fat was a potential confounder in our initial analyses. There was a significant correlation seen between fat mass determined by DXA and hip BMD, not a surprising finding given the significant increases in fat mass seen in each group. We also controlled for activity and intake of calcium and vitamin D, but no correlation was found between these variables and hip BMD, thus ruling out these variables as potential confounders. Theoretically, increases in hip BMD could be a biomechanical response, with the bone responding to and strengthened by the greater tissue mass around it. This issue is particularly.
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