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GYNECOLOGY&ANDROLOGY Net sales in the Gynecology&Andrology business area rose by 8%. Main sales driver was the oral contraceptive, Yasmin, with a net sales increase of 34%. Yasmin is the topselling oral contraceptive worldwide, with a global market share of approximately 13%. In the menopause management indication area, net sales increased by 5%, due in part to stocking effects of Climara. Two Phase III clinical trials with asoprisnil, a selective progesterone receptor modulator for the therapy of uterine fibroids, have been completed. The results of the trials are currently being evaluated together with our development partner TAP Pharmaceutical Products, Inc. Submission for registration of this product in Europe is planned in 2006.
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Persuasion: This technique universally identified, as the most common and most important in conciliation, is persuasion. It involves, the process of analyzing and understanding the party's perception on different issues and pursuing them to change their positions. The parties in conciliation use both coercive and persuasion tactics. Many a time, they threaten each other to induce the other party to step down. The conciliator must be conversant with the tactics of the parties and more particularly the way they put pressure on each other. The conciliator must allow the parties to uses the pressure tactics, but should prevent them to do so broadens the gaps. In perusing the parties to come closer he has to be particularly careful that one party does not see him as the spokesman of the other party. 4 ; Managing the conciliation process: Control of environment in which the conciliation progress is an important issue. The success in conciliation to a large extent depends on how the environment is managed and maintained. The environment should be such that the parties feel free to offer suggestions. The conciliation officer has to decide when to hold joint and separate meetings and who can attain the meetings and limit the number of participants from each side if required42. If any party is agitated it is his duty to cum him down for smooth progress in conciliation. Sometimes, diversionary talks may help lighten a tense situation, but the parties should not be unnecessarily carried too far. They should be encouraged to start serious discussions as soon as the situation permits. It is not unusual for the trade unions to make statements like `employers are out to exploit the working class' or `managers adopt various malpractices'. On the other hand, management may say that unions are unrealistic, without popular support and adopt various restrictive practices. Such arguments do not help the conciliation, so the parties should be asked to restrict their discussions to specific issues. 5 ; Integrating in dispute situation: One of the main problems for the conciliator is to integrate in the dispute situation. His achievement is dependent upon how well he is accepted as `one of us' by both the parties and how well he has grasped the disputes. He has to win the confidence of both the parties and establish him-self as a neutral, objective, and intelligent third party interested in the settlement of dispute. So long as the conciliation officer enjoys confidence of the concerned parties there is nothing arcane in it. The parties are sure to be relieved when they find that one always comes to any question without preconceived idea. An important principle is maintenance of secrecy, which the conciliation officer should always follow and specially after ending separate meetings when one party is eager to know the real position of the other party. Keeping confidentiality in issues that the parties want to share only with the conciliation officer is an important factor in building trust of the parties. The law also cast an obligation on the conciliation officer on matters marked as confidential. The conciliation officer must keep constant touch with the parties in conciliation and combivent.
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A total of 1, 530 patients were randomized and treated, including 1, 428 with a baseline biopsy and 1, 034 patients with a biopsy pre- and posttreatment. Characteristics of patients with paired biopsies were similar to the included population Table 1 ; . Prevalence of Steatosis Prior to Therapy. On the pretreatment biopsy, steatosis was present in 935 of 1, 428 patients 65% ; , including 175 83% ; of 210 patients with genotype 3 versus 760 62% ; of 1, 218 other genotypes P .001 ; . Among the 1, 034 patients with paired biopsies, steatosis was present in 670 patients 65% ; at baseline and in 571 patients at the end of follow-up 55% ; Table 2 ; . Factors Associated With Baseline Steatosis. Patients with baseline steatosis in comparison with patients without steatosis were older; more often male, with higher body mass index, higher blood glucose, higher serum triglycerides; and more often genotype 3, with higher fibrosis stage and higher activity grades Table 2 ; . The variables independently associated with baseline steatosis in logistic regression were genotype 3 OR 6.5, P .001 ; , triglycerides greater than 1.7 mmol L OR 3.3, P .001 ; , BMI greater than 27 and depakote.
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Up-To-Date", the database that provides comprehensive answers to clinical questions is now available in the Lee Memorial Hospital and HealthPark Medical Center libraries. In the HP library, it is installed on the computer facing the front desk. No passwords are necessary. Receive the current issue of The New England Journal of Medicine in your inbox every Thursday compliments of the Medical Library at LMHS. If you would like to receive the journal, please send your name, e-mail address and a phone number to: MedLibrary leememorial.
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Livermore DM 1998 ; . -lactamase mediated resistance and opportunities for its control. J. Antimicrob. Chemother. 41: 25-41. National Committee for Clinical Laboratory Standards. 2000 ; . Performance standards for antimicrobial disk susceptibility test 7th edition. Approval standard NCCLS, document M2- A7, Vol. 20; Wayne. Padmini B, Applaraju BS 2004 ; . Extended spectrum -lactamases in urinary isolates of E.coli and Klebsiella pneumoniae prevalence and susceptibility pattern in a tertiary care hospital. Indian J. Med. Microbiol. 22: 172-174. Paterson DL, Motiapatra SK, Vongottberg A 1997 ; . Klebsiella pneumoniae bacterium impact of extended spectrum -lactamases ESBL ; production in a global study of 216 patients abst ; in; program and abstract of the 37th inter science conference on antimicrobial agents and chemotherapy Washington, DC; Am. Soc. Microb. pp. 328. Philippon A, Labia R, Jacoby G 1989 ; . Extended spectrum lactamases, Antimicrob. Agents Chemother. 33: 1131-1136. Podschu R, Ullmann U 1998 ; . Klebsiella spp. as nosocomial pathogens; Epidemiology, Taxonomy, Typing Methods and Pathogenicity factors. Clin. Microbiol. Rev. 11: 589-603. Rice LE 1999 ; Successful interventions for gram negative resistance to extended spectrum -lactamases antibiotics. Pharmacotherapy. 19: 120-128. Subha A, Devi VR, Ananthan S 2003 ; . AmpC -lactase producing multi drug resistant strains of klebsiella spp, and Escherichia coli isolated from childrens under five in Chennai, India. Indian J. Med. Res. 117: 13-18. Sirot D 1995 ; . Extended spectrum plasmid mediated -lactamases. J. Antimicrob. Chemother. 36: suppl ; 19-34. Steward CD, Rasheed JK, Hubert SK, Biddle JW, Raney PM, Anderson G 2001 ; . Characterization of clinical isolates of Klebsiella pneumoniafrom 19 laboratories using the National Committee for Clinical Laboratory Standards, extended spectrum -lactamases detection methods. J. Clin. Microbiol. 39: 2864-2872.
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